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Alternative materials and Fabrication methods

Instead of using water-in-oil emulsion as the microarray carriers, we are now exploring the possibility of other types of encapsulation, such as hydrogel or other photocurable resins, to enable certain additional functionalities that were not achieved. We have also tried other innovative fabrication methods as an alternative approaches to make microfluidic systems.

Selected Project/Publications

1. Microfluidic Dielectrophoretic Method Enables On-Demand Spatial Arrangement of Bacteria-Encapsulated Agarose Gel Microparticles,
   J. Dai, C. Huang, H. Zhang, R. Samuel, Y. Li, A. Jayaraman, P. de Figueiredo, and A. Han,
   Analytical Chemistry, Vol. 94 (38), pp. 13197-13204 (2022)
2. ZrO2/ZnO/TiO2 Nanocomposite Coatings on Stainless Steel for Improved Corrosion Resistance, Biocompatibility
   M. Lee, S. -I. Han, C. Kim, S. Velumani, A. Han, A. H. Kassiba, and H. Castaneda,
   Applied Materials & Interfaces, Vol. 13, 13801-13811 (2022)
3. Generalizing Hydrogel Microparticles into a New Class of Bioinks for Extrusion Bioprinting,
   S. Xin, K. A. Deo, J. Dai, N. K. R. Pandian, D. Chimene, R. Moebius, A. Jain, A. Han, A. K. Gaharwar, D. L. Alge,
   Science Advances, Vol. 7 (42), eabk3087(2021)
4. Creating Physicochemical Gradients in Modular Microporous Annealed Particle Hydrogels via a Microfluidic Method,
   S. Xin, J. Dai, C. A. Gregory, A. Han, D. L. Alge,
   Advanced Functional Material, 1907102 (2019)

Microfluidic functional unit using 3D structures

Traditional fabrication of microfluidic systems uses soft lithography molds that typically come from 2.5-D lithography fabrication, resulting in very limited design flexibility along the Z-axis. With powerful high-resolution 3D photolithography tools, we proposed several novel microfluidic modules to reduce the operational errors that are somehow inevitable in traditional microfluidic systems.

Selected Project/Publications

1. High-aspect-ratio three-dimensional polymer and metallic microstructure microfabrication using two-photon polymerization,
   E Vargas, C Huang, Z Yan, H White, J Zou, and A Han,
   Biomedical Microdevices 25 (3), 28
2. Eliminating air bubble in microfluidic systems utilizing integrated in-line sloped microstructures,
   C Huang, JA Wippold, D Stratis-Cullum, and A Han,
   Biomedical Microdevices 22, 1-9
3. Enhancing droplet transition capabilities using sloped microfluidic channel geometry for stable droplet operation,
   JA Wippold, C Huang, D Stratis-Cullum, and A Han,
   Biomedical Microdevices 22, 1-5
4. A large-scale on-chip droplet incubation chamber enables equal microbial culture time,
   J Dai, HS Kim, AR Guzman, WB Shim, and A Han,
   Rsc Advances 6 (25), 20516-20519
5. A three-dimensional electrode for highly efficient electrocoalescence-based droplet merging,
   AR Guzman, HS Kim, P de Figueiredo, and A Han,
   Biomedical microdevices 17, 1-9

New hybrid “living” material discovery: ARL work

description

Selected Project/Publications

1. Identification of Microorganisms that Bind Specifically to Target Materials of Interest Using a Magnetophoretic Microfluidic Platform,
   Song-I Han, Deborah A Sarkes, Margaret M Hurley, Rebecca Renberg, Can Huang, Yuwen Li, Justin P Jahnke, James J Sumner, Dimitra N Stratis-Cullum, and Arum Han,
   ACS Applied Materials & Interfaces, Vol. 15 (9), pp. 11391-11402 (2023)
2. Discovery of Targeted Material Binding Microorganisms using a Centrifugal Microfluidic Platform,
   S. -I. Han*, D. A. Sarkes*, J. P. Jahnke, M. M. Hurley, V. M. Ugaz, R. Renberg, J. J. Sumner, D. N. Stratis-Cullum, and A. Han (*these authors contributed equally),
   Advanced Materials Technologies, Vol. 6, 2100282 (2021)
3. Integration of electrochemical impedance spectroscopy and microfluidics for investigating microbially influenced corrosion using co-culture biofilms,
   SP Kotu, C Erbay, N Sobahi, A Han, S Mannan, and A Jayaraman,
   NACE CORROSION, NACE-2016-7793

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