In vitro Microphysiological System (MPS)
Microphysiological system (MPS), also known as Organ-on-Chip (OOC) or tissue chip, demonstrates complex three-dimensional structures and in vivo functions of specific organ through multicellular cultivation, hence utilizing simple 2D cell culture have major limitations. We have been developing organ-specific in vitro systems for developing therapeutics, conducting toxicological studies, conducting mechanistic studies, and many more.
Topics
Female Reproductive Systems
We have been developing organ-on-a-chip systems of female reproductive organ systems, especially related to preterm birth, for therapeutic development, toxicological studies, and mechanistic studies. These include fetal membrane OOC, placenta OOC, vagina-cervix interface OOC, to name a few. Both healthy and disease OOC models have been developed.
Selected Project/Publications
- Development of oxidative stress-associated disease models using feto-maternal interface organ-on-a-chip
Lauren Richardson, Ananth Kumar Kammala, Sungjin Kim, Po Yi Lam, Nina Truong, Enkhtyua Radnaa, Rheanna Urrabaz-Garza, Arum Han, Ramkumar Menon,
FASEB J. 2023 Jul; 37(7) - Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy
Lauren Richardson, Ananth K Kammala, Maged M Costanitine, Stephen J Fortunato, Enkhtuya Radnaa, Sungjin Kim, Robert N Taylor, Arum Han, Ramkumar Menon,
Lab on a Chip, 2022 Nov 22;22(23):4574-4592 - Modeling ascending Ureaplasma parvum infection through the female reproductive tract using vagina-cervix-decidua-organ-on-a-chip and feto-maternal interface-organ-on-a-chip
Ourlad Alzeus G Tantengco, Lauren S Richardson, Enkhtuya Radnaa, Ananth Kumar Kammala, Sungjin Kim, Paul Mark B Medina, Arum Han, Ramkumar Menon,
FASEB J. 2022 Oct;36(10) - Exosomes from Ureaplasma parvum-infected ectocervical epithelial cells promote feto-maternal interface inflammation but are insufficient to cause preterm delivery
Ourlad Alzeus Ourlad Alzeus G Tantengco, Lauren S Richardson, Enkhtuya Radnaa, Ananth Kumar Kammala, Sungjin Kim, Paul Mark B Medina, Arum Han, Ramkumar Menon,
Frontier Cell Dev Biol. 2022 Aug - Molecular mechanisms of environmental toxin cadmium at the feto-maternal interface investigated using an organ on chip (FMi-OOC) model
Sungjin Kim, Lauren Richardson, Enkhtuya Radnaa, Zunwei Chen, Ivan Rusyn, Ramkumar Menon, Arum Han.
Journal of Hazardous Materials, 422 (2022) 126759 - Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth
Enkhtuya Radnaa, Lauren S Richardson, Samantha Sheller-Miller, Tuvshintugs Baljinnyam, Mariana de Castro Silva, Ananth Kumar Kammala, Rheanna Urrabaz-Garza, Talar Kechichian, Sungjin Kim, Arum Han, Ramkumar Menon,
Lab on a Chip. 2021 May 18;20(10):1956-1973 - Modeling ascending infection with a feto-maternal interface organ-on-chip
Lauren S Richardson, Sungjin Kim, Arum Han, Ramkumar Menon,
Lab on a Chip. 2020 Nov 24;20(23):4486-4501 - Organ-on-Chip Technology: The Future of Feto-Maternal Interface Research?
Lauren Richardson, Sungjin Kim, Ramkumar Menon, Arum Han,
Frontiers in Physiology 2020 June
Blood Brain Barrier (BBB)
Developing OOC systems of the blood-brain barrier (BBB) to test the permeability of various chemical compounds that can help develop therapeutics against neurological disorders.
Selected Project/Publications
- A three-dimensional arrayed microfluidic blood-brain barrier model with integrated electrical sensor array
Sehoon Jeong, Sunja Kim, John Buonocore, Jaewon Park, C. Jane Welsh, Jianrong Li, Arum Han,
IEEE transactions on biomedical engineering, vol. 64, No.2, 2018
Neuronal co-culture system
Developing in vitro microfluidic co-culture systems for studying neural systems.
Selected Project/Publications
- Multi-compartment neuron-glia co-culture platform for localized CNS axon-glia interaction study
Jaewon Park, Hisami Koito, Jianrong Li, Arum Han,
Lab on a Chip, 2012, 12, 3296-3304 - Micro-macro hybrid soft-lithography master (MMHSM) fabrication for lab-on-a-chip applications
Jaewon Park, Jianrong Li, Arum Han,
Biomed Microdevices, 2010, 12:345-351