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NanoBio Systems Lab

Texas A&M University

Texas A&M University College of Engineering
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High-throughput single-cell-resolution microfluidic technical development

High-throughput Single-cell-resolution Microfluidics Technology Development

We have been developing various single-cell manipulation technologies in the format of both free-flow and droplet-based microfluidic system. Whether it is a detection method, such as fluorescence, Raman spectroscopy, electrical impedance; or a manipulation method, such as acoustophoresis, dielectrophoresis, or magnetophoresis; we have made many fundamental technological advancements that have the potential to be broadly utilized in many different microfluidic lab-on-a-chip applications.

 

Topics

Single-cell Manipulation Technologies

Developing single-cell manipulation technologies for on-demand controls in microfluidic systems

Selected Project/Publications

  1. Acoustofluidic Microdevice for Precise Control of Pressure Nodal Positions
    S. Yigit, H. Wang, S. -I. Han, Y. H. Cho, and A. Han,
    Microfluidics and Nanofluidics, Vol. 24, 52 (2020)
  2. Separation, Characterization, and Handling of Microalgae by Dielectrophoresis
    V. Abt, F. Gringel, A. Han, P. Neubauer, and M. Birkholz,
    Microorganisms,8(4), 540 (2020)
  3. Raman Spectroscopy Compatible PDMS Droplet Microfluidic Culture and Analysis Platform towards On-Chip Lipidomics
    H. S. Kim*, S. C. Waqued*, D. T. Nodurft, T. P. Devarenne, V. V. Yakovlev, and A. Han (*these authors contributed equally),
    Analyst, Vol. 142, pp. 1054-1060 (2017)

 

Single-cell Sensing Technologies

Developing novel sensing and detection technologies that can be integrated into microfluidic lab-on-a-chip systems

Selected Project/Publications

  1. Measurement of Dielectric Properties of Cells at Single-Cell Resolution Using Electrorotation
    Y. Li, C. Huang, S. -I. Han, and A. Han,
    Biomedical Microdevices, Vol. 24, 23 (2022)
  2. High-Throughput and Label-Free Multi-Outlet Cell Counting Using a Single Pair of Impedance Electrodes
    N. Sobahi and A. Han,
    Biosensors and Bioelectronics, Vol. 166, 12458 (2020)
  3. Impedance Spectroscopy-based Cell/Particle Position Detection in Microfluidic Systems
    H. Wang*, N. Sobahi*, and A. Han (*these authors contributed equally),
    Lab on a Chip, Vol. 17, pp. 1264-269 (2017)
  4. Microfluidic Acoustophoretic Force Based Low Concentration Oil Separation and Detection from Environment
    H.Wang, Z.Liu, C. Koo, S. Kim, Y. Cho, D. -Y. Jang, Y. -J. Kim, and A. Han,
    Lab on a Chip, Vol. 14, pp. 947-956 (2014)

 

Microdroplet Manipulation Technologies

Advancing droplet microfluidic manipulation technologies, especially focusing on high efficiency, low error, and integrability.

Selected Project/Publications

  1. FIDELITY: A quality control system for droplet microfluidics
    Han Zhang, Can Huang, Yuwen Li, Rohit Gupte, Ryan Samuel, Jing Dai, Adrian Guzman, Rushant Sabnis, Paul de Figueiredo, Arum Han,
    Science Advances, Vol. 8 (27), pp. eabc9108 (2022)
  2. Cell Washing and Solution Exchange in Droplet Microfluidic Systems
    C. Huang*, H. Zhang*, S. -I. Han, and A. Han (*these authors contributed equally),
    Analytical Chemistry, Vol. 93 (24), 8622-8630 (2021)
  3. In-droplet Cell Separation based on Bipolar Dielectrophoretic Response to Facilitate Cellular Droplet Assays
    S. Han*, C. Huang*, and A. Han (*these authors contributed equally),
    Lab on a Chip, Vol. 20, pp. 3832-3841 (2020)
  4. An Ultra High-Efficiency Droplet Microfluidics Platform using Automatically Synchronized Droplet Pairing and Merging
    H. Zhang*, A. Guzman*, J. Wippold, Y. Li, J. Dai, C. Huang, and A. Han (*these authors contributed equally),
    Lab on a Chip, Vol. 20, pp. 3948-3959(2020)
  5. In-Droplet Cell Concentration using Dielectrophoresis
    S. Han, H. Kim, and A. Han,
    Biosensors and Bioelectronics, Vol. 97, pp. 41-45 (2017)

 

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